In the mid 1980’s, a group of transplant patients at the University of Pittsburgh Medical Center saw the need for an organization to help transplant recipients and candidates cope with the challenges they experienced in the transplant process. Out of this group TRIO was established, and in 1987 was incorporated as a not-for-profit organization. It was soon determined that TRIO could best serve the transplant community by becoming an international organization and in 1994 moved its headquarters to Washington D.C.
TRIO continues to serve transplant recipients in many regions of the nation, with chapters in California, Texas, Washington D.C., New York, Ohio, Florida, Kansas and Pennsylvania. In addition, there are international chapters in Japan and Italy.